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为探讨 p5 3、 c- erb B- 2蛋白表达与食管鳞癌生物学行为的关系 ,应用免疫组化 L SAB法研究 181例食管鳞癌中p5 3、 c- erb B- 2蛋白的表达。结果发现 ,正常食管粘膜均无 p5 3、c- erb B- 2蛋白的表达。 47%食管鳞癌出现 p5 3表达 ,p5 3阳性病例癌旁非典型增生上皮出现 p5 3表达 ,p5 3阴性病例癌旁非典型增生上皮亦为阴性。p5 3阳性表达率与患者年龄、性别、肿瘤大小、组织学分级 ,临床 TNM分期无关 ,且与预后无关。 5 1.4%食管鳞癌呈现 c- erb B- 2蛋白表达 ,癌旁非典型增生上皮无 c- erb B- 2表达。c- erb B- 2阳性率与肿瘤组织学分级、浸润深度、淋巴结转移及肝转移有关 ,c- erb B- 2阳性表达者预后较差。结果提示 ,p5 3表达在食管鳞癌发生中起重要作用 ;c- erb B- 2表达在食管鳞癌浸润转移中起重要作用。同时进行 p5 3、 c-erb B- 2蛋白免疫组化检测 ,有助于对食管鳞癌进行早期诊断 ,监测病情和判断预后。
To investigate the relationship between the expression of p53, c-erb B-2 protein and the biological behavior of esophageal squamous cell carcinoma, the expression of p5 3 and c-erb B-2 protein in 181 cases of esophageal squamous cell carcinoma was studied by immunohistochemical L SAB method. The results showed that no normal esophageal mucosa p5 3, c-erb B-2 protein expression. 47% esophageal squamous cell carcinoma appeared p5 3 expression, p5 3 positive cases of adjacent atypical hyperplastic epithelial p5 3 expression, p5 3 negative cases adjacent to the atypical hyperplastic epithelium is also negative. The positive rate of p5 3 was not related to the patient’s age, sex, tumor size, histological grade, clinical TNM stage, and had no relationship with the prognosis. 5 1.4% esophageal squamous cell carcinoma showed c-erb B-2 protein expression, adjacent non-atypical hyperplasia epithelial no c-erb B-2 expression. The positive rate of c-erb B-2 correlated with tumor histological grade, depth of invasion, lymph node metastasis and liver metastasis, and the positive expression of c-erb B-2 was poor prognosis. The results suggest that p5 3 expression plays an important role in the carcinogenesis of esophageal squamous cell carcinoma; c-erb B-2 expression plays an important role in the invasion and metastasis of esophageal squamous cell carcinoma. At the same time, the detection of p5 3, c-erb B-2 protein immunohistochemistry is helpful for early diagnosis of esophageal squamous cell carcinoma, monitoring of disease and prognosis.