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目的探讨食管多通道腔内阻抗联合24小时p H监测观察胆囊排空功能对胃食管反流的影响。方法选择150例胃食管反流病患者,根据病症分为胆结石组、胆息肉组和胆囊正常组,利用脂餐刺激法计算胆囊排空率,利用MII-p H监测食管反流情况。最后评价GERD症状严重程度与胆囊排空功能的变化。结果胆结石组胆囊无论是空腹或进食脂质后大小都较其他两组大(P<0.05),而其胆囊排空率均比其余两组小(P<0.05),液体反流次数增加(P<0.05)。结论胆结石患者胆囊排空功能明显障碍;MII-p H可检测出GERD伴胆结石的患者反流加重、其成分更复杂;胆囊排空功能的异常会导致GERD反流情况的加重,但并不会明显改变患者的自觉症状。
Objective To investigate the effect of esophageal multi-channel intraluminal impedance combined with 24-hour p H monitoring on the gastroesophageal reflux. Methods 150 patients with gastroesophageal reflux disease were selected and divided into gallstone group, gallbladder polyp group and normal gallbladder group according to the condition. Gallbladder emptying rate was calculated by dietary stimulation method. Esophageal reflux was monitored by MII-p H. Finally, evaluate the severity of GERD and the changes of gallbladder emptying function. Results The gallbladder of gallstone group was larger than that of the other two groups (P <0.05), but its gallbladder emptying rate was smaller than that of the other two groups (P <0.05) and the number of liquid reflux increased P <0.05). Conclusions Gallbladder patients have obvious obstruction of gallbladder emptying function. MII-p H can detect GERD with gallstone in patients with reflux regurgitation, its composition is more complicated; Gallbladder emptying function abnormalities will lead to GERD reflux, but Will not significantly change the patient’s symptoms.