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姜黄药用的主要有效成分是姜黄素,曾被认为是理想的抗癌化学治疗药物之一,然而,姜黄素在水中的溶解度低,体内吸收少,生物利用度低,极大地限制了它的应用。采用乳化聚合的方法,成功地制备了粒径在250nm左右的表面带正电荷的聚氰基丙烯酸正丁酯包载的姜黄素纳米粒,该纳米姜黄素仍然保留了姜黄素本身的生物活性,可抑制人肝癌细胞株HepG2细胞的生长,阻滞细胞周期于G2/M期,对HepG2细胞有抗增殖作用,能诱导细胞凋亡,下调在肿瘤血管生长中起重要作用的血管内皮生长因子和调控血管内皮生长因子的环氧合酶-2的表达。
Curcumin, the main active ingredient of curcuma, is considered as one of the ideal anticancer chemotherapeutic drugs. However, curcumin has low solubility in water, less in vivo absorption and low bioavailability, which greatly limits its application. By using the method of emulsion polymerization, the positively charged poly (n-butyl polycyanoacrylate) -based curcumin nanoparticles with a diameter of about 250 nm were successfully prepared. The curcumin still retained the biological activity of curcumin itself, Can inhibit the growth of human hepatoma HepG2 cells, arrest the cell cycle in G2 / M phase, have anti-proliferation effect on HepG2 cells, induce apoptosis, down-regulate the expression of vascular endothelial growth factor and vascular endothelial growth factor Regulates Cyclooxygenase-2 Expression in Vascular Endothelial Growth Factor.