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目的 研究尿激酶型纤溶酶原激活物受体 (uPAR)和组蛋白酶D(CD)在胃癌浸润和转移过程中所起的作用。方法 采用免疫组化检测 5 9例胃癌组织中uPAR和CD的表达 ,观察它们与胃癌组织学类型、浸润深度以及淋巴结转移的关系。结果 5 9例中uPAR阳性 2 8例。在乳头状、管状腺癌和粘液腺癌中uPAR阳性率较高 ,而在低分化癌和印戒细胞癌中阳性率较低 (P <0 .0 1)。在CD中则无此差异 (P >0 .0 5 ) ;有淋巴结转移组uPAR阳性率为 6 0 .5 3% (2 3/38) ,高于无淋巴结转移组的 2 3.81% (5 /2 1) (P <0 .0 1) ,CD在淋巴结转移阳性组和阴性组阳性率分别为 79.4 9% (31/39)和 5 0 .0 0 % (10 /2 0 ) (P <0 .0 5 ) ;uPAR在早期胃癌组阳性率为 12 .5 0 % (1/8) ,侵及肌层组阳性率为 37.5 0 % (6 /16 ) ,侵犯全层组阳性率为 6 0 .0 0 % (2 1/35 ) ,差别有显著性 (P <0 .0 5 ) ,CD中则无显著差异 (P >0 .0 5 )。结论 uPAR、CD与胃癌的浸润和转移密切相关 ,uPAR与胃癌组织学类型有关。
Objective To investigate the role of urokinase-type plasminogen activator receptor (uPAR) and histone deacetylase (CD) in the process of gastric cancer invasion and metastasis. Methods Immunohistochemistry was used to detect the expression of uPAR and CD in 59 cases of gastric carcinoma and their relationship with histological type, depth of invasion and lymph node metastasis were observed. Results In 59 cases, uPAR was positive in 28 cases. The positive rates of uPAR were higher in papillary, tubular adenocarcinoma and mucinous adenocarcinoma, but lower in poorly differentiated carcinoma and signet-ring cell carcinoma (P <0.01). There was no difference in CD (P> 0.05). The positive rate of uPAR in patients with lymph node metastasis was 60.33% (2 3/38), which was higher than that in patients without lymph node metastasis (23.81% The positive rate of CD was 79.4 9% (31/39) and 50.0% (10/20) respectively in the lymph node positive group and negative group (P <0 2 01) 0.05). The positive rate of uPAR in early gastric cancer group was 12.5% (1/8), the positive rate in invasive muscle group was 37.5% (6/16), and the positive rate of uPAR in invasive group was 60 .0 0% (2 1/35), the difference was significant (P <0.05), but there was no significant difference in CD (P> 0.05). Conclusions uPAR and CD are closely related to the infiltration and metastasis of gastric cancer, and uPAR is related to the histological type of gastric cancer.