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将49例有胃食道反流症状、食道pH监测有病理性胃食道反流的患者随机分成两组(其中25例有内镜下食道炎)。一组用雷尼替丁(300mg,2次/d)加西沙必利(5mg,3次/d)(n=25);另一组单用雷尼替丁(300mg,2次/d)(n=24)治疗,疗程4周。结果显示:胃食道反流症状的好转率分别为88.00％、58.33％(P<0.05);食道pH值有效率分别为92.00％、54.17％(P<0.05);内镜下食道炎的愈合率分别为84.62％、50.00％(P>0.05)。以上结果表明:抑制胃酸分泌的药物与促动力剂合用是控制胃食道反流性疾病的最佳方法之一。
Forty-nine patients with symptoms of gastroesophageal reflux disease and esophageal pH monitoring with pathologic gastroesophageal reflux were randomly divided into two groups (25 of whom had endoscopic esophagitis). One group received ranitidine (300 mg twice a day) plus cisapride (5 mg, 3 times daily) (n = 25), and the other ranitidine alone (300 mg twice daily) (n = 24) for 4 weeks. The results showed that the improvement rate of gastroesophageal reflux symptom was 88.00% and 58.33% respectively (P <0.05); the effective rate of esophageal pH was 92.00% and 54.17% respectively (P <0.05); the healing rate of endoscopic esophagitis Respectively 84.62%, 50.00% (P> 0.05). The above results show that: inhibition of gastric acid secretion drugs and promoters combined is one of the best ways to control gastroesophageal reflux disease.