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目的探讨中老年女性腰围(WC)、腰臀比(WHR)及高血压与发生子宫肌瘤(UL)危险性的关系。方法采用以医院为基础的研究方法,选择612例35～65岁女性,患者均经超声诊断或手术确诊的子宫肌瘤患者,对照组为因患其他疾病同期入住与病例相同医院的患者。采用调查表对研究对象进行调查,包括人口学特征、生活方式以及既往史等,同时对身高、体重、WC及臀围进行测量。采用多因素Logistic回归模型对患者WC、WHR及高血压与UL的比值比(OR)及其相应的95%CI进行估计。结果 WC和WHR升高使发生UL的危险性增加(OR=1.504,95%CI:1.068～2.119,P=0.019;OR=1.524,95%CI:1.107～2.097,P=0.010);罹患高血压的女性与UL呈正相关(OR=1.505,95%CI:1.046～2.165,P=0.028)。与收缩压为最低四分位数的对照相比,第3个四分位数的病例发生UL的危险性较高(OR=1.675,95%CI:1.053～2.663,P=0.029)。当调整了多种潜在性混杂因素后,WC、WHR及高血压与UL关系的结果并未发生改变。结论向心性肥胖和高血压可能是发生UL的重要危险因素。
Objective To investigate the relationship between waist circumference (WC), waist-to-hip ratio (WHR) and the risk of developing uterine fibroids (UL) in middle-aged and elderly women. Methods A hospital-based research method was used to select 612 patients with uterine fibroids diagnosed by ultrasonography or surgery from 35 to 65 years old. The control group was patients admitted to the same hospital with the same disease due to other diseases. Surveys were used to investigate subjects, including demographic characteristics, lifestyle, and past history, while measuring height, weight, WC, and hip circumference. Multivariate Logistic regression models were used to estimate the ratio of patients with WC, WHR, and the odds ratio (OR) of 95% CI and corresponding hypertension. Results The increase of WC and WHR increased the risk of developing UL (OR = 1.504, 95% CI: 1.068-2.1119, P = 0.019; OR = 1.524,95% CI: 1.107-2.097, P = 0.010) Of women had positive correlation with UL (OR = 1.505, 95% CI: 1.046-2.16 5, P = 0.028). Patients in the third quartile had a higher risk of developing UL with a systolic blood pressure of the lowest quartile (OR = 1.675, 95% CI: 1.053-2.663, P = 0.029). The WC, WHR, and the relationship between hypertension and UL did not change after adjusting for several potential confounders. Conclusion Concentric obesity and hypertension may be important risk factors for the occurrence of UL.