多个循证医学都证实波动性高血糖要比稳定性高血糖对心血管并发症更有独立的伤害作用。波动性高血糖更能促进多元醇通路、已糖胺通路、蛋白激酶C及HGE的活性,也更能使氧化应激放大,使粘附因子增加,这些都是内皮细胞伤害的主要因素。当前造成血糖波动的主要原因是餐后高血糖和医 Multiple evidence-based medical studies have demonstrated that fluctuating hyperglycemia is more independent of cardiovascular complications than stable hyperglycemia. Fluctuating hyperglycemia is more likely to promote polyol pathway, glycosaminoglycan pathway, protein kinase C and HGE activity, but also to enlarge the oxidative stress and increase the adhesion factor, which are the main factors of endothelial cell injury. The main reason for the current fluctuations in blood glucose is postprandial hyperglycemia and medical