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[目的]观察Livin蛋白在皮肤基底细胞癌、脂溢性角化病等表皮肿瘤中的表达情况。[方法]采用免疫组化和流式细胞术检测Livin蛋白在30例脂溢性角化病和15例皮肤基底细胞癌皮损中的表达情况,以20例正常皮肤组织作为对照。并采用流式细胞术对标本进行Livin蛋白定量分析。[结果]Livin蛋白在基底细胞癌中表达(86.67%)高于在脂溢性角化病组织(53.33%)和正常皮肤组织(5%)的表达(P<0.05),在30例脂溢性角化病皮损中,Livin蛋白阳性表达量高于在正常20例皮肤组织中的表达(P<0.05)。[结论]脂溢性角化病和皮肤基底细胞癌的发生发展可能与Livin蛋白的异常表达有关。
[Objective] To observe the expression of Livin in epidermal tumors such as skin basal cell carcinoma and seborrheic keratosis. [Method] The expression of Livin protein in 30 cases of seborrheic keratosis and 15 cases of skin basal cell carcinoma lesions were detected by immunohistochemistry and flow cytometry. Twenty normal skin tissues were used as control. Flow cytometry was used to quantify Livin protein in the specimens. [Results] The expression of Livin protein in basal cell carcinoma (86.67%) was higher than that in seborrheic keratosis (53.33%) and normal skin tissues (5%) (P <0.05) In keratosis lesions, the positive expression of Livin protein was higher than that in normal skin tissues (P <0.05). [Conclusion] The occurrence and development of seborrheic keratosis and cutaneous basal cell carcinoma may be related to the abnormal expression of Livin protein.