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长效单纯孕激素避孕效果好,不影响血压,也不增加静脉血栓形成的危险,但破坏月经周期,尤其是应用的前几个月。子宫内膜小血管由内皮细胞及其周围基底膜组成,基底膜有三个重要成分:IV型胶原蛋白、网板和肝素硫酸脂蛋白糖(HSPG)。基底膜增加血管强度,其结构或完整性的改变能引起血管脆性增加及突破性出血。本研究目的是对正常月经分泌期和Norplant埋植后1～9个月,子宫内膜内皮细胞基底膜的特性进行比较性研究,探讨其变化与突破性出血的关系。
Long-acting simple progestin contraceptive effect, does not affect blood pressure, does not increase the risk of venous thrombosis, but the destruction of the menstrual cycle, especially in the first few months of use. Endometrial small blood vessels by the endothelial cells and the surrounding basement membrane, the basement membrane has three important components: type IV collagen, stencil and heparin sulfate proteoglycan (HSPG). Basement membrane increases vascular strength, and changes in its structure or integrity can cause an increase in vascular fragility and breakthrough bleeding. The purpose of this study was to compare the characteristics of the basement membrane of endometrial endothelial cells between the secretory phase of normal menstruation and 1 to 9 months after implantation of Norplant to explore the relationship between the changes and breakthrough bleeding.