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目的:观察七氟醚后处理对非体外冠状动脉旁路移植术患者的心肌保护作用。方法:选取2019年4月至2020年4月山东省平原县中医院收治的68例行非体外冠状动脉旁路移植术的患者，随机分为两组。对照组不采取任何干预措施，观察组则采取七氟醚后处理，即最后一条血管吻合开放前2 min持续吸入七氟醚至吻合口开放8 min后，共计吸入七氟醚10 min。比较两组患者不同时点生命体征(血压和心率)以及血清生化指标(肌酸磷酸激酶同工酶、肿瘤坏死因子-α)的变化。结果:麻醉诱导前两组患者的血压和心率差异无统计学意义(均n P>0.05)，冠状动脉重建完毕时以及冠状动脉重建后1 h观察组的血压及心率均明显高于对照组(均n P0.05)，冠状动脉重建后1 h以及6 h时观察组的肌酸磷酸激酶同工酶以及肿瘤坏死因子-α水平均明显低于对照组(均n P0.05). The blood pressure and heart rate of the observation group at the completion of coronary artery reconstruction and 1 hour after coronary artery reconstruction were significantly higher than those of the control group (n P0.05). The levels of creatine phosphokinase isoenzyme and tumor necrosis factor-alpha were significantly lower in the observation group at 1 h and 6 h after coronary artery remodeling than those in the control group (n P< 0.05).n Conclusions:The application of sevoflurane post-treatment in non-external coronary artery bypass grafting can help reduce the fluctuation of vital signs, decrease the expression of inflammatory factors, thereby protect cardiomyocytes.