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目的：探讨 FOXP3基因及其编码的 FOXP3蛋白在结直肠癌组织中的表达情况与结直肠癌发展和转移的关系。方法采用免疫组织化学技术分别检测50例结直肠癌组织、29例结直肠腺瘤组织及15例正常结直肠黏膜组织中 FOXP3蛋白的表达情况。结果 FOXP3蛋白在正常结直肠黏膜、结直肠腺瘤、结直肠癌组织中阳性率分别为6.7%、31.0%、86.0%。结直肠癌组织中 FOXP3蛋白的表达显著高于正常结直肠黏膜和结直肠腺瘤组织（P <0.05），且 FOXP3蛋白的表达与结直肠癌的浸润深度、淋巴结转移有相关性（P 0.05）。结论 FOXP3基因在结直肠癌的发生和转移中有重要作用，FOXP3的高表达可能与机体抗肿瘤免疫有关。“,”Objective To investigate the expression of FOXP3 gene encoding protein in colorec-tal cancer tissue and its correlation with development and metastasis of colorectal cancer. Methods To detect FOXP3 protein expression level of 50 cases of colorectal cancer tissue,29 cases of colorectal ade-noma,15 cases of normal colorectal mucosa by immunohistochemistry technique. Results The positive rate of FOXP3 protein in normal colorectal mucosa,colorectal adenoma and colorectal cancer tissues was 6. 7% ,31. 0% and 86. 0% respectively. The expression of FOXP3 in colorectal cancer tissue protein was significantly higher than that in normal colorectal mucosa and colorectal adenoma tissue(P < 0. 05), and the expression of FOXP3 protein was correlated with invasion depth,lymph node metastasis of color-ectal cancer( P 0. 05). Conclusions FOXP3 gene plays an important role in the occurrence and metastasis of colorectal cancer,and high expression of FOXP3 may be related to the antitumor immunity.