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目的 :探讨局部外用三合激素 (雌激素、孕激素、雄激素 )治疗外阴上皮内非瘤样病变的临床疗效。方法 :对我科近 5年来病理确诊的外阴上皮内非瘤样病变病人 5 3例 ,随机分为 2组 ,以局部外用三合激素加蜂蜜作为观察组 (35例 ) ,以局部外用 2 %氢化可的松霜为对照组 (18例 ) ,两组病例分别对症状、体征、皮肤弹性、颜色及病理检查等方面进行比较。结果 :观察组治愈 2 4例 (6 7% ) ,显效 6例 (17% ) ,有效 2例 (5 .7% ) ,无效 2例 (5 .7% ) ,总有效率 94 .3% ;对照组治愈 0例 (0 % ) ,显效 5例(2 8% ) ,有效 8例 (44 % ) ,无效 5例 (2 8% ) ,总有效率 72 %。两组各指标比较P值均 <0 .0 1,有非常显著性统计学意义。结论 :三合激素加蜂蜜是治疗外阴上皮内非瘤样病变一种疗效显著、使用简便的治疗方法。
Objective: To investigate the clinical effect of topical triad hormone (estrogen, progesterone and androgen) in the treatment of non-neoplasia lesions in the vulva epithelium. Methods: Fifty-three patients with intravaginal intraepithelial neoplasia confirmed pathologically in our department in recent 5 years were randomly divided into 2 groups. Topical triadole plus honey as observation group (35 cases), topical 2% Hydrocortisone cream for the control group (18 cases), two groups of patients were symptoms, signs, skin elasticity, color and pathological examination and other aspects were compared. Results: In the observation group, 24 cases (67%) were cured, 6 cases (17%) were markedly effective, 2 cases (5 .7%) were effective, 2 cases (5 .7%) were ineffective and the total effective rate was 94.3%. The control group was cured in 0 cases (0%), markedly effective in 5 cases (28%), effective in 8 cases (44%), ineffective in 5 cases (28%), the total effective rate was 72%. The P value of each index of two groups were <0. 01, there is a very significant statistical significance. Conclusion: Triple therapy plus honey is a non-xenograft intravaginal intraepithelial lesion with a significant effect and easy to use treatment.