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目的观察不同运动水平对新诊断肥胖T2DM患者代谢指标、胰岛功能及IS的影响。方法将74例新诊断肥胖T2DM患者随机分为强化运动组(强化组)及一般运动组(对照组),两组均予糖尿病知识健康教育、饮食管理、小剂量二甲双胍(0.5g/d);强化组运动200～250min/周,对照组运动100～150min/周。干预8周及16周后对两组血脂、血压、BMI、FBG、FIns、FC-P、HbA1c、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)及胰岛素初期相分泌指数(△I30/△G30)进行比较。结果干预8周后强化组TG、TC、HbA1c、HOMA-IR明显低于对照组(P<0.05或P<0.01);16周后强化组0min及60min血糖、TG、DBP、BMI、HbA1c,以及HOMA-IR明显低于对照组(P<0.05或P<0.01);HDL-C、FC-P及HOMA-β明显高于对照组(P<0.05或P<0.01)。结论新诊断肥胖T2DM患者通过增加运动量有益于代谢指标及胰岛功能的进一步改善。
Objective To observe the effects of different exercise levels on the metabolic parameters, islet function and IS in newly diagnosed obese T2DM patients. Methods Totally 74 newly diagnosed obese T2DM patients were randomly divided into intensive exercise group (exercise group) and general exercise group (control group). The two groups were given diabetes knowledge and health education, diet management, low dose metformin (0.5g / d) Intensive group exercise 200 ~ 250min / week, control group exercise 100 ~ 150min / week. The levels of blood lipid, blood pressure, BMI, FBG, FIns, FC-P, HbA1c, insulin resistance index (HOMA-IR), insulin secretion index (HOMA-β) and initial insulin secretion index △ I30 / △ G30) for comparison. Results The levels of TG, TC, HbA1c and HOMA-IR in the intensive group were significantly lower than those in the control group (P <0.05 or P <0.01) after 8 weeks of intervention. The levels of TG, DBP, BMI and HbA1c in the intensive group at 0 and 60 minutes HOMA-IR was significantly lower than that of the control group (P <0.05 or P <0.01); HDL-C, FC-P and HOMA-β were significantly higher than those of the control group (P <0.05 or P <0.01). Conclusions Newly diagnosed obese T2DM patients benefit from further improvement of metabolic parameters and islet function through increased exercise.