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目的探讨低体重儿母亲妊娠期的主要危险因素,为今后防治工作提供依据。方法系统收集1998年1月-2014年10月中国低体重儿危险因素的相关文献;按照NOS标准对纳入文献进行质量评价;采用Stata 12.0软件对纳入的文献进行Meta分析。结果最终纳入13篇文献,共研究对象10 636例,经Meta分析计算合并OR值及其95%CI有统计学意义的因素为:高龄(≥35岁)1.99(1.22~3.25)、妊娠期高血压3.81(2.63~5.52)、贫血1.55(1.04~2.30)、被动吸烟2.08(1.17~3.70)、孕期反应强烈2.19(1.10~4.76)、孕期食欲差2.69(2.18~3.31)、流产史1.36(1.02-1.81)、胎盘异常3.17(2.14~4.71)。结论孕母高龄、妊娠期高血压、贫血、被动吸烟、孕期食欲差、孕期反应强烈、流产史及胎盘异常是影响中国低体重儿发生的母亲妊娠期主要危险因素。
Objective To explore the main risk factors of pregnancy in low birth weight mothers and to provide basis for future prevention and treatment. Methods The related literatures about risk factors of low birth weight infants in China from January 1998 to October 2014 were collected. The quality of the included documents was evaluated according to NOS standards. Meta analysis was performed on the included documents using Stata 12.0 software. The results of the final inclusion of 13 articles, a total of 10 636 cases of study, the Meta analysis of the combined OR and its 95% CI were statistically significant factors: elderly (≥ 35 years old) 1.99 (1.22 ~ 3.25), gestational high The blood pressure was 3.81 (2.63-5.52), anemia was 1.55 (1.04-2.30), passive smoking was 2.08 (1.17-3.70), during pregnancy was strongly 2.19 (1.10-4.76), pregnancy expectancy was 2.69 (2.18-3.31), abortion history was 1.36 (1.02 -1.81), placental abnormalities 3.17 (2.14 ~ 4.71). Conclusion Maternal pregnancy, pregnancy-induced hypertension, anemia, passive smoking, poor appetite during pregnancy, strong reaction during pregnancy, miscarriage history and abnormal placenta are the main risk factors of pregnancy during low birth weight infants in China.