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目的探讨血清胱抑素C(Cystatin,Cys-C)对慢性心力衰竭(Chronic Heart Failure,CHF)患者早期肾功能损害的诊断价值。方法选择2009年2～10月在我院急诊科住院的心脏病患者62例,并将其分为A、B两组。A组31例为无原发性肾脏病变的慢性心力衰竭患者,B组31例为无心力衰竭心脏病患者,另选32例健康志愿者作为健康对照组,设为C组。分别测定A、B、C三组Cys-C、血清肌酐(SCr)、尿素氮(Bun)及血清β2-微球蛋白(β2-MG)水平,并进行统计分析。结果A组与B、C组相比,Bun、SCr、β2-MG差异无统计学意义(P>0.05),而A组与B、C组相比,血Cys-C差异有统计学意义(P<0.01)。结论无原发性肾脏病变的心衰患者存在以肾小球滤过功能受损为特征的早期肾功能异常;心衰程度愈重,肾功能损伤愈明显,Cys-C检测可用于CHF患者早期肾脏损害诊断。
Objective To investigate the diagnostic value of serum cystatin C (Cys-C) in early renal damage in patients with chronic heart failure (CHF). Methods 62 cases of heart disease hospitalized in emergency department of our hospital from February to October 2009 were selected and divided into A and B groups. A group of 31 patients without primary renal disease in patients with chronic heart failure, B group of 31 patients without heart failure heart disease, another 32 healthy volunteers as the healthy control group, as the C group. The levels of Cys-C, serum creatinine (SCr), blood urea nitrogen (Bun) and serum β2-microglobulin (β2-MG) in A, B and C groups were measured and statistically analyzed. Results There was no significant difference in Bun, SCr and β2-MG between group A and group B and C (P> 0.05), but there was a significant difference in Cys-C between group A and B and C P <0.01). Conclusions There is an early renal dysfunction characterized by impaired glomerular filtration in patients with heart failure without primary renal disease. The more severe heart failure, the more obvious renal dysfunction. The detection of Cys-C can be used in the early stage of CHF Diagnosis of kidney damage.