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目的 :探讨肺癌患者测定血清p5 3抗体的临床意义。方法 :采用ELISA法检测 12 0例肺癌患者术前血清p5 3抗体 ,并以 30例肺部良性疾病患者和 12 0例正常健康人作对照。结果 :(1)肺癌患者血清p5 3抗体水平和阳性率均明显高于肺部良性疾病患者和正常人 (P <0 0 5 )而正常人与肺部良性疾病患者间无显著差异 (P >0 0 5 )。 (2 )肺癌患者血清p5 3抗体水平和阳性率均与肺癌细胞分化程度和病期有密切关系 (P <0 0 1或P <0 0 5 )。结论 :检测血清p5 3抗体有助于肺部良恶性疾病的诊断 ;术前测定有助于判断肺癌进展和分期。
Objective: To investigate the clinical significance of serum p5 3 antibody in patients with lung cancer. Methods: Preoperative serum p5 3 antibody was detected in 120 lung cancer patients by ELISA, and 30 patients with benign pulmonary disease and 120 healthy controls were used as controls. Results: (1) The level and positive rate of serum p5 3 antibody in patients with lung cancer were significantly higher than those in patients with benign lung diseases and normal controls (P <0.05), but there was no significant difference between normal subjects and patients with benign lung diseases (P> 0 0 5). (2) The level and positive rate of serum p5 3 antibody in lung cancer patients are closely related to the differentiation degree and disease stage (P <0.01 or P <0.05). Conclusion: Detection of serum p5 3 antibody is helpful for the diagnosis of benign and malignant pulmonary diseases. Preoperative determination is helpful to judge the progress and stage of lung cancer.