C反应蛋白(CRP)是一种急性时相蛋白,在炎症或组织破坏时将升高.1930年Tillet和Francis首先在急性肺炎病人的血清中发现了此种蛋白.它能与肺炎球菌细胞膜中的C多糖一起沉淀,这种依赖钙离子的反应不像真正的抗原-抗体反应.1941年Macleod等研究了CRP的抗原性.他们发现兔抗CRP血清不仅与提纯了的CRP起反应, C-reactive protein (CRP) is an acute phase protein that rises upon inflammation or tissue destruction. Tillet and Francis first discovered this protein in the serum of patients with acute pneumonia in 1930. It binds to the pneumococcal membrane Of C polysaccharides precipitate, this calcium-dependent reaction is not like a true antigen-antibody reaction. Macleod et al. Studied the antigenicity of CRP in 1941. They found that rabbit anti-CRP serum not only reacted with the purified CRP,