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作者报告一例急性淋巴细胞性白血病晚期患者出现意向性肌阵挛,并附有尸检材料。患者为印刷工人,23岁,因体重减轻,腰痛和贫血而于1969年2月27日住院,周围血象和骨髓检查,异常细胞明显增加,主要为成淋巴细胞,诊断为急性淋巴细胞性白血病。曾输血并给予氨甲喋呤冶疗无效,病情继续恶化,9月13日血红蛋白9.75克,红细胞278万/立方毫米,白细胞4800/立方毫米,76％为成淋巴细胞。髂嵴骨髓穿刺发现大量白血病细胞。9月17日开始出现意向性肌阵挛和轻度发音障碍,9月18日腰穿,脑脊液混浊,压力370毫米水柱,细胞总数2000/立方毫米,几乎都是白血病细胞,蛋白75毫克
The authors report an intention myoclonus in a late-stage patient with acute lymphoblastic leukemia with autopsy material. The patient, a printing worker, aged 23, was hospitalized on February 27, 1969 due to weight loss, back pain and anemia. Peripheral blood and bone marrow tests revealed a significant increase in abnormal cells, mainly lymphoblasts, diagnosed as acute lymphoblastic leukemia. Blood transfusion and methotrexate treatment ineffective, the condition continued to worsen, September 13 hemoglobin 9.75 grams, 278,000 / cubic mm erythrocytes, white blood cells 4800 / cubic mm, 76% into lymphocytes. Iliac crest bone marrow puncture found a large number of leukemia cells. Sept. 17 began to appear intentional myoclonus and mild dysphonia, September 18 lumbar puncture, cerebrospinal fluid turbidity, pressure 370 mm water column, the total number of cells 2000 / cubic mm, almost all leukemia cells, protein 75 mg