目的:建立早期股骨头坏死模型,为研究其发病机制及合理治疗方法的提供可靠的模型基础。方法:用单一剂量脂多糖LPS(10μg/kg)联合三次甲强龙MPS(10 mg/kg)注射,每次间隔24h,诱导建立兔早期股骨头坏死模型,通过影像学及组织病理性学方法评估模型建立情况。结果:4周后,模型组死亡1例,模型组16例X线检查未见异常表现,2例X线提示股骨头密度不均,未出现股骨头塌陷,18例HE染色示骨细胞空骨陷窝增多,脂肪细胞体积变大,数量增多。结论:用脂多糖(LPS)联合甲强龙可成功诱导建立兔早期股骨头坏死模型,模型成功率高、死亡率低。 Objective: To establish an early model of osteonecrosis of the femoral head and provide a reliable model foundation for studying its pathogenesis and reasonable treatment. Methods: A single dose of lipopolysaccharide LPS (10μg / kg) combined with three times of methylprednisolone MPS (10 mg / kg) injection, each interval of 24h, induced the establishment of rabbit model of early osteonecrosis, by imaging and histopathological methods Assess the establishment of the model. Results: After 4 weeks, there were 1 death in the model group and 16 cases in the model group. No abnormality was found in X - ray examination of 2 cases. X - ray showed uneven femoral head density and no femoral head collapse. Eighteen cases of osteoblasts were observed by HE staining. Increased lacuna, fat cells become larger, the number increased. CONCLUSION: LPS combined with methylprednisolone can successfully induce early rabbit model of osteonecrosis of the femoral head. The model has high success rate and low mortality rate.