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目的连续监测急性脑梗死(ACI)患者病后各个阶段血清中游离脂肪酸(FFA)水平改变,探究其在ACI中的临床意义。方法纳入ACI患者40例,运用甘油氧化酶比色法测定所有研究对象病后2d以内和其中19例d7血清FFA的水平;选同期就诊本院体检中心的中老年者20例为对照组。结果患者ACI2d内和d7FFA浓度分别为(455.8±161.0)μmol/L和(292.5±121.8)μmol/L,同对照组FFA浓度(122.8±15.2)μmol/L相比较,差异皆有统计学意义(P﹤0.01)。此外,发病后2d内血清FFA浓度与d7血清FFA浓度相比较,差异也有统计学意义(P﹤0.01)。结论 ACI患者病后血清FFA水平升高明显,随病情好转其水平下降。
Objective To continuously monitor the changes of serum free fatty acid (FFA) levels in patients with acute cerebral infarction (ACI) at different stages of disease and to explore its clinical significance in ACI. Methods Forty patients with ACI were enrolled in this study. The levels of serum FFA within 2 days after operation and 19 cases with d7 were measured by glycerol oxidase colorimetric assay. Twenty patients with senile dementia were selected as the control group. Results The intra-ACI2d and d7FFA concentrations were (455.8 ± 161.0) μmol / L and (292.5 ± 121.8) μmol / L, respectively, which were significantly different from those of the control group (122.8 ± 15.2 μmol / L) P <0.01). In addition, the serum FFA concentration within 2 days after onset compared with the serum FFA concentration of d7, the difference was also statistically significant (P <0.01). Conclusions Serum FFA levels in patients with ACI increased significantly, and their levels decreased as the condition improved.