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热休克蛋白(heat shock protein,HSP)由Ritossa在1962年研究果蝇唾液腺染色体时首先发现,是一类广泛存在于自然界生物体内、具有重要生理功能且高度保守的蛋白质。在正常细胞中有少量表达,约占细胞总蛋白的5%~10%,当细胞处于高温、感染、创伤、缺氧及恶性肿瘤等应激状态下,其表达明显增强,故又称为应激蛋白(stress protein,SP)。研究证实,热休克
Heat shock protein (HSP) was first discovered by Ritossa in 1962 when studying Drosophila salivary gland chromosomes. It is a kind of highly conserved protein with extensive physiological functions and widespread in nature. In normal cells there is a small amount of expression, accounting for 5% to 10% of total cellular protein, when the cells are in high temperature, infection, trauma, hypoxia and malignant tumors and other stress conditions, its expression was significantly enhanced, it is also known as Stress protein (SP). Studies confirm that heat shock