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目的观察阿托伐他汀预防脑梗死复发的作用。方法将保定市徐水县人民医院2010年1月至2011年1月收治的76例脑梗死患者分为研究组和对照组,两组均采用常规治疗,对照组采用阿司匹林,研究组在对照组的基础上采用阿托伐他汀,比较两组患者的神经功能缺损程度和日常生活能力,颈动脉内膜-中层厚度(IMT)及颈动脉斑块面积的改善,1年内的死亡率和复发率及不良反应。结果研究组的神经功能缺损评分、日常生活能力、颈动脉内膜-中层厚度(IMT)及颈动脉斑块面积的改善显著优于对照组(P<0.05)。研究组1年内的死亡率、复发率显著低于对照组(P<0.05)。结论阿托伐他汀可抑制脑梗死的斑块形成,减轻延缓,甚至逆转颈动脉粥样硬化的进展,防止脑梗死复发。
Objective To observe the effect of atorvastatin in preventing the recurrence of cerebral infarction. Methods 76 patients with cerebral infarction admitted to Xishui County People’s Hospital of Baoding from January 2010 to January 2011 were divided into study group and control group. Both groups were treated with conventional therapy, aspirin in control group and control group Atorvastatin was used to compare the degree of neurological impairment and daily living ability, the improvement of carotid intima-media thickness (IMT) and carotid plaque area, the mortality and relapse rate within one year And adverse reactions. Results The neurological deficit scores, daily living ability, carotid intima - media thickness (IMT) and carotid plaque area in the study group were significantly better than those in the control group (P <0.05). The mortality and recurrence rates of the study group within one year were significantly lower than those of the control group (P <0.05). Conclusion Atorvastatin can inhibit the formation of cerebral infarction plaque, reduce the delay or even reverse the progress of carotid atherosclerosis and prevent the recurrence of cerebral infarction.