DKK1作为Wnt信号传导通路的拮抗剂,在肿瘤发生发展中发挥重要的作用。近年来的研究表明,DKK1作为一种分泌型糖蛋白,在多种肿瘤患者血清中呈高表达,可能在肿瘤中发挥重要的临床作用。本文就血清DKK1在肿瘤临床应用中的价值作一综述。 As an antagonist of Wnt signaling pathway, DKK1 plays an important role in tumorigenesis. Recent studies have shown that DKK1, as a secreted glycoprotein, is overexpressed in sera of various tumor patients and may play an important clinical role in tumors. This article reviews the value of serum DKK1 in the clinical application of tumors.