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目的探讨原发性肾病综合征(PNS)并发急性肾损伤(AKI)的相关因素,为PNS并发AKI的诊断、预防和治疗提供参考。方法对98例PNS患者的临床资料进行回顾性分析,对PNS并发AKI的相关因素进行分析。结果 PNS并发AKI的发病率为8.16%。单因素分析结果显示,年龄、感染、重度浮肿、24 h尿蛋白、24 h尿量、Hb、Bun/Scr与PNS并发AKI有关(P<0.05);而性别、血白蛋白与PNS并发AKI无明显相关性(P>0.05)。结论 PNS并发AKI的发病率与年龄有关,以老年患者多见;感染是PNS并发AKI的诱因;PNS患者出现重度浮肿,且24 h尿蛋白量显著增加而24 h尿量显著减少,伴有Hb和Bun/Scr水平升高的PNS患者提示可能并发AKI。
Objective To investigate the related factors of primary nephrotic syndrome (PNS) complicated with acute kidney injury (AKI) and provide reference for the diagnosis, prevention and treatment of PNS complicated with AKI. Methods The clinical data of 98 PNS patients were retrospectively analyzed, and the related factors of PNS complicated with AKI were analyzed. Results The incidence of PNS complicated with AKI was 8.16%. Univariate analysis showed that age, infection, severe edema, 24 h urinary protein, 24 h urine output, Hb, Bun / Scr were associated with PNS complicated with AKI (P <0.05), while sex, serum albumin and PNS complicated with AKI Significant correlation (P> 0.05). Conclusions The incidence of PNS complicated with AKI is related to age and is more common in elderly patients. Infection is the cause of PNS complicated with AKI. Severe edema occurred in PNS patients. The urinary protein in 24 h increased significantly while the urine output in 24 h decreased significantly accompanied by Hb And patients with PNS with elevated Bun / Scr levels may be associated with AKI.