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目的观察贞芪扶正冲剂联合EP方案治疗晚期小细胞肺癌的疗效及毒副作用。方法治疗组10例,对照组10例,均采用相同的EP方案:VP-16 100 mg/m2第1～3天,DDP30 mg/m2第1～3天,3周为一周期,治疗组应用贞芪扶正冲剂2包3次/d热水冲服,连续服用。结果两组疗效无显著性差异(P>0.005)治疗组血液毒副作用和消化道不良反应发生率明显低于对照组有显著性差异(P<0.005)。结论贞芪扶正冲剂联合EP方案治疗晚期小细胞肺癌可降低化疗对患者的毒副作用,改善患者生活质量,提高化疗耐受性。
Objective To observe the curative effect and side effects of Zhenqi Fuzheng Granule combined with EP regimen in the treatment of advanced small cell lung cancer. Methods The treatment group (n = 10) and the control group (n = 10) received the same EP regimen: VP-16 100 mg / m2 on days 1 to 3, DDP 30 mg / m2 on days 1 to 3 and 3 weeks for one cycle. Zhenqi Fu Zheng granules 2 packs 3 times / d hot water Chongfu, taking continuously. Results There was no significant difference between the two groups (P> 0.005). The incidence of side effects of blood and side effects of gastrointestinal tract in the treatment group were significantly lower than those in the control group (P <0.005). Conclusion Zhenqi Fuzheng granules combined with EP regimen in the treatment of advanced small cell lung cancer can reduce the side effects of chemotherapy on patients, improve the quality of life of patients and improve the tolerance of chemotherapy.