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[目的]观察大黄导泻联合西药治疗急性有机磷农药中毒疗效。[方法]使用随机平行对照方法,将124例住院患者按病志号抽签法简单随机分为两组。对照组62例常规治疗,清理皮肤、洗胃、灌肠,20%甘露醇,250m L/次,3次/d,口服导泻,危重患者应特效药对症治疗。治疗组62例大黄导泻(大黄粉30g,绿豆60g,甘草30g),1剂/d,水煎200m L,洗胃后先口服甘露醇导泻,再服大黄解毒剂;甘露醇用法同对照组。连续治疗2d为1疗程。观测临床症状、排便时间、排便次数、住院时间、不良反应。连续治疗3疗程,判定疗效。[结果]治疗组痊愈21例,显效31例,有效8例,无效2例,总有效率96.77%。对照组痊愈18例,显效29例,有效8例,无效7例,总有效率88.71%。治疗组疗效优于对照组(P<0.05)。相关指标治疗组改善优于对照组(P<0.05)。[结论]大黄导泻联合西药治疗急性有机磷农药中毒疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of rhubarb catharsis combined with western medicine on acute organophosphorus pesticide poisoning. [Methods] Using randomized parallel control method, 124 inpatients were randomly divided into two groups according to the random number of patients by lottery. Control group, 62 cases of conventional treatment, cleaning the skin, gastric lavage, enema, 20% mannitol, 250m L / time, 3 times / d, oral catharsis, critically ill patients should be treated with symptomatic drugs. The treatment group, 62 cases of rhubarb catharsis (rhubarb powder 30g, mung bean 60g, licorice 30g), 1 / d, decoction 200m L, gastric lavage after oral administration of mannitol catharsis, and then serving rhubarb antidote; group. Continuous treatment 2d for a course of treatment. Observation of clinical symptoms, defecation, defecation frequency, length of stay, adverse reactions. Continuous treatment of 3 courses to determine the efficacy. [Results] The treatment group cured 21 cases, markedly effective in 31 cases, effective in 8 cases, 2 cases, the total effective rate was 96.77%. The control group cured 18 cases, markedly effective in 29 cases, effective in 8 cases, ineffective in 7 cases, the total effective rate was 88.71%. The treatment group was better than the control group (P <0.05). Correlation index treatment group improved better than the control group (P <0.05). [Conclusion] Rhubarb cathartic combined with western medicine is effective in treating acute organophosphorus pesticide poisoning without serious adverse reactions and is worth promoting.