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目的研究与分析重症监护患者的镇痛镇静治疗效果及应用意义。方法 80例重症监护患者为研究对象,利用计算机将其随机分为观察组与对照组,各40例。观察组采用枸橼酸舒芬太尼联合吗啡治疗,对照组采用丙泊酚以及冬非合剂间断治疗。观察比较两组治疗效果。结果观察组视觉模拟评分为(2.57±0.84)分,明显低于对照组的(5.86±0.91)分,差异具有统计学意义(P<0.05)。观察组患者唤醒时间为(0.14±0.06)h,明显短于对照组的(1.53±0.57)h,差异具有统计学意义(P<0.05)。观察组发生心动过缓1例、血压下降2例、自主呼吸频率变化显著1例,不良反应发生率为10.0%(4/40);对照组发生心动过缓3例、血压下降4例、自主呼吸频率变化显著4例,不良反应发生率为27.5%(11/40);观察组不良反应发生率明显低于对照组,差异具有统计学意义(P<0.05)。结论采用枸橼酸舒芬太尼联合吗啡治疗重症监护患者后,能达到良好的镇痛镇静效果,且不会对血流动力学产生影响,值得应用于临床推广。
Objective To study and analyze the analgesic and sedation effect of intensive care patients and its clinical significance. Methods Eighty patients with intensive care were selected as study subjects. They were randomly divided into observation group and control group with 40 cases in each group. The observation group was treated with sufentanil citrate combined with morphine, and the control group was treated intermittently with propofol and Dong Fei Mixture. Observed and compared the treatment effect. Results The visual analogue scale of the observation group was (2.57 ± 0.84) points, which was significantly lower than that of the control group (5.86 ± 0.91) points, the difference was statistically significant (P <0.05). The awake time of the observation group was (0.14 ± 0.06) h, which was significantly shorter than that of the control group (1.53 ± 0.57) h, the difference was statistically significant (P <0.05). In the observation group, 1 case had bradycardia and 2 cases blood pressure decreased. The frequency of spontaneous respiration was significantly changed in 1 case and the rate of adverse reactions was 10.0% (4/40). The control group had 3 cases of bradycardia and 4 cases of decreased blood pressure. The respiratory rate was significantly changed in 4 cases, the incidence of adverse reactions was 27.5% (11/40). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P <0.05). Conclusion Sufentanil combined with morphine citrate treatment of intensive care patients, can achieve good analgesic and sedation, and will not affect the hemodynamics, it is worth to apply in clinical promotion.