以排泄功能为特征的肾脏血流约为心输出量的20%,通过肾小球的超滤和肾小管的浓缩过程肾脏经常暴露于高浓度的药物作用之下。因此,进入体内的多种药物可引起功能或器质性肾损害。非甾体抗炎药(NSAIDs)不仅作为一般用药,在与人口老龄化相关的变形性关节炎、腰痛等应用也较多,近年 The renal blood flow characterized by excretory function is about 20% of cardiac output, and the kidneys are often exposed to high concentrations of drugs through the glomerular ultrafiltration and tubular condensation process. Therefore, a variety of drugs into the body can cause functional or organic renal damage. Non-steroidal anti-inflammatory drugs (NSAIDs) not only as a general drug, and in the aging population associated with osteoarthritis, low back pain and other applications are also more recent years