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目的 :探讨血清可溶性细胞间粘附分子 -1(sICAM -1)水平与胃癌临床病理指标的关系 ,评价检测胃癌患者sICAM -1的临床意义。方法 :应用酶联免疫吸附法分别检测34例治疗前胃癌患者及20例正常人血清中可溶性细胞间粘附分子 -1的含量。结果 :胃癌组及正常人对照组血清sICAM -1含量分别为367 7±104 7ng/ml,236 9±74 3ng/ml,两者有显著差异(P<0 001)。胃癌患者按临床病理特征分组 ,肿瘤直径≥5cm组、高临床期别(Ⅲ～Ⅳ)组和淋巴结转移组的各组血清sICAM -1含量较其相应对照组显著提高。结论 :血清sICAM -1水平的检测对评价胃癌患者病情和预后有一定意义
Objective: To investigate the relationship between serum soluble intercellular adhesion molecule-1 (sICAM-1) and clinicopathological parameters in gastric cancer and to evaluate the clinical significance of sICAM-1 in gastric cancer. Methods: Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) were detected by enzyme-linked immunosorbent assay in 34 patients with pre-treatment gastric cancer and 20 normal controls. Results: The levels of sICAM - 1 in gastric cancer group and normal control group were 367 7 ± 104 7ng / ml and 236 9 ± 74 3ng / ml, respectively, with significant difference (P <0.001). The patients with gastric cancer were divided into groups according to the clinicopathological features. The levels of sICAM-1 in each group with tumor diameter≥5cm, high clinical stage (Ⅲ ~ Ⅳ) and lymph node metastasis were significantly higher than those of the corresponding control group. Conclusion: The detection of serum sICAM-1 level has certain significance in evaluating the condition and prognosis of patients with gastric cancer