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采用微波法合成PLA和PLA-PEG-PLA,以PLA和PLA-PEG-PLA的粘均分子量和得率为评价指标,对微波功率和微波反应时间进行了单因素实验。以合成的PLA-PEG-PLA为药物载体,采用乳化-溶剂挥发法制备了(Po-dophyllotoxin,PPT)/PLA-PEG-PLA载药微球,考察了载药微球的药物缓释性能。通过傅立叶变换红外光谱(FT-IR)、扫描电子显微镜(SEM)对微波法合成的PLA和PLA-PEG-PLA以及制备的载药微球的微观结构进行了表征分析。结果表明,最佳微波功率为200W,最佳反应时间为30min时,合成的三元嵌段共聚物PLA-PEG-PLA的粘均分子量为5.2×103。体外释药研究表明,PPT/PLA-PEG-PLA-MS具有明显的药物缓释性。
The PLA and PLA-PEG-PLA were synthesized by microwave method. The visco-average molecular weight and yield of PLA and PLA-PEG-PLA were evaluated to evaluate the microwave power and microwave reaction time. Po-dophyllotoxin (PPT) / PLA-PEG-PLA loaded microspheres were prepared by the emulsification-solvent evaporation method using the synthesized PLA-PEG-PLA as the drug carrier, and the sustained-release properties of the loaded microspheres were investigated. The microstructure of PLA, PLA-PEG-PLA and microspheres prepared by microwave method were characterized by Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The results showed that the viscosity average molecular weight of the synthesized ternary block copolymer PLA-PEG-PLA was 5.2 × 103 when the optimum microwave power was 200W and the optimum reaction time was 30min. In vitro release studies have shown that, PPT / PLA-PEG-PLA-MS has a significant drug release.