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目的:探讨艾滋病合并肺结核的临床治疗管理模式。方法:148例艾滋病合并肺结核患者按治疗模式分为单纯抗结核治疗组(A组,21例)、强化抗结核治疗序贯抗病毒治疗组(B组,103例)和抗病毒联合抗结核治疗组(C组,24例),比较三组的用药依从性、临床疗效以及不良反应情况。结果:三组患者的用药依从性均为100%,三组的治疗成功率无明显差异(P>0.05),C组的中断治疗率显著高于A、B组,A、C组的死亡率显著高于B组(P<0.05);三组治疗后CD4+淋巴细胞计数均显著提高(P<0.05);A组的不良反应率显著低于B、C组(P<0.05)。结论:早期诊断并合理选择治疗管理模式对改善艾滋病合并肺结核的临床预后、降低不良反应率具有重要意义。
Objective: To explore the clinical management of AIDS with tuberculosis. Methods: A total of 148 patients with AIDS complicated with pulmonary tuberculosis were divided into two groups according to the treatment mode: anti-tuberculosis therapy group (A group, n = 21), antituberculosis intensive therapy (group B, n = 103) (C group, 24 cases). The compliance, clinical efficacy and adverse reactions of the three groups were compared. Results: The medication adherence of the three groups was 100%. There was no significant difference between the three groups (P> 0.05). The discontinuation of treatment in group C was significantly higher than that in groups A, B, A and C (P <0.05). The CD4 + lymphocyte counts of all three groups were significantly increased (P <0.05). The adverse reaction rate of group A was significantly lower than that of group B and C (P <0.05). Conclusion: Early diagnosis and reasonable choice of management mode of treatment to improve the clinical prognosis of AIDS with pulmonary tuberculosis, reduce the adverse reaction rate is of great significance.