【摘 要】
：
A dual-receptor targeting delivery system based on acid-cleavage hydrazone bond was developed in the study. The characters of CMCS-hyd-CUR-EGFR- mAb were identified. The in vitro release studies revealed that this drug delivery system was acid-sensitive,
【机 构】
：
Department of Phamaceutical Engineering, School of Chemistry, Chemical Engineering and Life Sciences
【出 处】
：
武汉理工大学学报（材料科学版）（英文版）
论文部分内容阅读
A dual-receptor targeting delivery system based on acid-cleavage hydrazone bond was developed in the study. The characters of CMCS-hyd-CUR-EGFR- mAb were identified. The in vitro release studies revealed that this drug delivery system was acid-sensitive, and the self-assembled nanoparticles which were spherical. The in vitro results indicated that the dual-receptor targeting nanoparticles could be faster internalized into the Cal-27 cells via receptor-mediated endocytosis, which exhibited better antitumor activity than the one-receptor nanoparticles. The experimental results clearly reveal that CMCS-hyd-CUR-EGFR mAb provides a novel way for drug delivery in oral cancer treatment.
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