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本文报告使用国产尼群地平20mg治疗14例高血压病的急性血流动力学变化。发现它具有较强降压效应,有效率79％,血压平均下降3.4/1.9kPa(26/15mmHg)。超声心动图检查发现左心室收缩与舒张期腔径减小,射血分数和平均周径纤维缩短率增大,总周围血管阻力降低,但心率、心搏量与心输出量无变化。提示尼群地平在体内同时具有动、静脉扩张作用。
This article reports the use of domestic nitrendipine 20mg in the treatment of 14 cases of hypertensive patients with acute hemodynamic changes. It was found to have a strong antihypertensive effect, with an effective rate of 79% and an average blood pressure drop of 3.4 / 1.9kPa (26 / 15mmHg). Echocardiography showed that left ventricular systolic and diastolic cavities decreased, ejection fraction and mean circumferential fiber shortening rate increased, total peripheral vascular resistance decreased, but heart rate, stroke volume and cardiac output did not change. Prompted nitrendipine in the body at the same time with the dynamic and venous dilatation.