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目的 :探讨硬化治疗在食管静脉曲张硬化治疗后食管、贲门癌发生中的作用。方法 :收集文献报道的 2 6例和我院 4例患者的临床资料分析食管静脉曲张硬化治疗后食管、贲门癌的发生状况 ,发生部位及其与注射部位 ,注射药物种类、剂量关系 ,治疗结束至发现肿瘤的时间。结果 :(1)肿瘤发生部位分散于食管中上 1/ 3、中 1/ 3、中下 1/ 3、下 1/ 3和贲门区与硬化治疗注射部位并非完全一致 ,(2 )肿瘤发生与硬化剂种类无明确关系 ,常用的各种硬化剂均有食管或贲门癌的病例发现 ,(3)发生肿瘤的病例 ,除 1例外硬化剂总用量均大于或等于 30ml,(4 )硬化治疗结束平均 19 4个月 (4～ 77个月 )发现肿瘤。结论 :硬化治疗在食管静脉曲张硬化治疗后食管、贲门癌的发生中起某种促进作用 ,这一作用可能是通过硬化剂对局部粘膜的化学性致炎作用而达成的 ,食管静脉曲张硬化治疗后有必要进行定期内镜复查
Objective: To investigate the role of sclerotherapy in the pathogenesis of esophageal and gastric cardia after esophageal varicosis sclerosis. Methods: The clinical data of 26 cases reported in our hospital and 4 cases in our hospital were collected to analyze the incidence of esophageal and gastric cardia cancer after esophageal variceal sclerosis, the location and its relationship with the site of injection, the type and dose of injection, the end of treatment To find the time of the tumor. Results: (1) The site of tumor spread was 1/3, 1/3, 1/3, 1/3, 1/3 and cardiac area in the esophagus were not completely consistent with the injection site of sclerotherapy. (2) There is no clear relationship between the types of sclerotherapy, commonly used in all cases of esophageal or cardia cancer sclerotherapy found cases, (3) the occurrence of tumor cases, except 1 total amount of sclerosing agents are greater than or equal to 30ml, (4) the end of sclerotherapy An average of 19 4 months (4 to 77 months) found the tumor. Conclusions: Sclerotherapy may play an important role in the development of esophagus and gastric cardia after esophageal variceal sclerosis. This effect may be caused by the chemical inflammatory effect of sclerosant on the local mucosa. Esophageal varicose vein sclerosis After the need for regular endoscopic review