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目的:探讨地诺前列酮(欣普贝生)用于非胰岛素治疗的足月妊娠期糖尿病引产的有效性及安全性。方法:选择有引产指征的非胰岛素治疗的足月妊娠期糖尿病孕妇79例,其中欣普贝生组48例,对照组(催产素组)31例,比较两组的引产效果及分娩情况。结果:实验组促宫颈成熟率为93.75%,对照组为48.39%,实验组用药至临产时间、总产程均短于对照组,剖宫产率低于对照组,差异有统计学意义(P<0.01),实验组在产后出血、胎儿窘迫、分娩期血糖变化方面与对照组差异无统计学意义。结论:非胰岛素治疗的妊娠期糖尿病足月妊娠应用地诺前列酮栓引产与催产素相比成功率高、产程短,可提高阴道分娩率,降低剖宫产率,是安全有效的引产方式,值得临床推广。
Objective: To investigate the efficacy and safety of dinoprostone (Xin P bei sheng) in induction of full-term gestational diabetes with non-insulin therapy. Methods: A total of 79 pregnant women with gestational diabetes mellitus who were induced by induction of labor were enrolled. Among them, 48 were enbupazine group and 31 were control group (oxytocin group). The induction of labor and childbirth were compared between the two groups. Results: The rate of cervical ripening was 93.75% in the experimental group and 48.39% in the control group. The duration of labor and the duration of labor in the experimental group were shorter than those in the control group, and the cesarean section rate was lower than that in the control group (P < 0.01). There was no significant difference between the experimental group and the control group in terms of postpartum hemorrhage, fetal distress and changes of blood glucose during labor. Conclusion: Non-insulin-gestation gestational diabetes mellitus using full-term droperidol supposition with oxytocin compared with high success rate, short duration of labor, can improve vaginal delivery rate, reduce the rate of cesarean section, is a safe and effective induction of labor, Worth clinical promotion.