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目的 观察基因重组α - 2b干扰素治疗儿童慢性乙型肝炎疗效。方法 将 10 8例慢性乙型肝炎患儿分为治疗组 78例、对照组 30例 ,治疗组给予α - 2b干扰素治疗 ,疗程半年 ,治疗后观察肝功能及HBV标志。结果 治疗组HBeAg及HBV -DNA转阴率分别为 39 7%和 38 5 % ,均显著高于对照组 (P <0 0 1) ,丙氨酸转氨酶 (ALT)复常率、HBsAg转阴率分别为 96 2 %、5 1% ,与对照组无显著性差异 (P >0 0 5 )。结论 基因重组α - 2b干扰素是治疗小儿慢性乙型肝炎的有效药物 ,其疗效与ALT水平、年龄等因素有关
Objective To observe the effect of recombinant interferon α - 2b on chronic hepatitis B in children. Methods A total of 108 children with chronic hepatitis B were divided into treatment group (n = 78) and control group (n = 30). The treatment group was given α - 2b interferon for half a year. After treatment, liver function and HBV markers were observed. Results The negative rates of HBeAg and HBV DNA in the treatment group were 39 7% and 38 5%, respectively, which were significantly higher than those in the control group (P 0 01), normalization rate of alanine aminotransferase (ALT), negative conversion rate of HBsAg Respectively, 96 2%, 51%, no significant difference with the control group (P> 0 05). Conclusion Recombinant interferon alfa - 2b is an effective drug for the treatment of chronic hepatitis B in children. The therapeutic effect is related to the level of ALT, age and other factors