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目的探讨慢性充血性心力衰竭(CHF)患者血清N-末端脑钠肽前体(NT-proBNP)和肌酐(Cr)水平变化及相关性。方法 72例CHF患者,分为LVEF>40%组(40例)和LVEF≤40%组(32例);40例健康体检者作为对照组。检查血NT-proBNP、Cr和测定LVEF。结果血清NT-proBNP和Cr水平为LVEF≤40%组>LVEF>40%组>对照组(P均<0.01);CHF患者血清NT-proBNP与Cr水平呈正相关,LVEF与血清NT-proBNP和Cr水平均呈负相关。结论 CHF患者血清NT-proBNP和Cr水平与心功能有关,测定NT-proBNP和Cr水平有助于判断病情,指导治疗。
Objective To investigate the changes and correlations of serum N-terminal pro brain natriuretic peptide (NT-proBNP) and creatinine (Cr) in patients with chronic congestive heart failure (CHF). Methods Seventy-two CHF patients were divided into 40 cases (LVEF> 40%) and 32 cases (LVEF≤40%). Forty healthy subjects were used as control group. Blood NT-proBNP, Cr and LVEF were examined. Results Serum levels of NT-proBNP and Cr were positively correlated with Cr levels in patients with LVEF≤40%, LVEF> 40%, and control group (all P <0.01). Serum levels of NT-proBNP and Cr were positively correlated with serum levels of NT-proBNP and Cr The levels were negatively correlated. Conclusion The serum levels of NT-proBNP and Cr in CHF patients are related to cardiac function. The levels of NT-proBNP and Cr can be helpful to judge the condition and guide the treatment.