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神经营养因子(NTF)通常是指一组能支持神经元发育和存活的、自然存在的小分子多肽.近年来NTF研究取得了引人瞩目的进展,使NTF迅速从研究室推向临床.1996年5月23～24日在英国伦敦召开了神经营养因子:临床应用和前景会议.会上报告的许多临床前和临床研究结果证明,对于中枢神经系统(CNS)和周围神经系统(PNS)的许多神经变性疾病和神经元损伤,可用NTF预防、减慢病程发展或者甚至逆转病程.初期研究集中于与天然人NTF序列相同或有高度同源性的重组NTF,而目前,越来越多地研究其经过修饰的类似物和合成的模拟物以及新的给药方法.
Neurotrophic factor (NTF) usually refers to a group of naturally occurring small molecule peptides that can support the development and survival of neurons.In recent years, NTF research has made remarkable progress, so that NTF rapidly from the research room to the clinic .1996 Neurotrophic factors: Clinical Applications and Prospective Meetings were held in London, England from May 23 to May 24. Many of the preclinical and clinical studies reported at the meeting demonstrated that for the central nervous system (CNS) and the peripheral nervous system (PNS) Many neurodegenerative and neuronal injuries can be prevented with NTF, slowing the progression of disease or even reversing the course of the disease.Preliminary studies have focused on recombinant NTF that is identical or highly homologous to native human NTF sequences, and more and more Study its modified analogs and synthetic mimics as well as new drug delivery methods.