体外实验中,各种肾脏细胞都能在特定刺激下表达趋化因子及受体。动物模型和人类肾脏疾病的肾组织中,炎症细胞浸润同时出现趋化因子及受体表达增多。ENA-78是一种来源广泛、生物功能多样的趋化因子,通过与其受体相互作用,引起中性粒细胞等白细胞的趋化、活化,参与肾脏疾病的发生、发展。 In vitro experiments, a variety of kidney cells can express specific chemokines and receptors. Animal models and kidney disease in human kidney tissue, inflammatory cell infiltration while chemokines and receptor expression increased. ENA-78 is a kind of chemotactic factor with a wide range of sources and diverse biological functions. It interacts with its receptors to cause chemotaxis and activation of leukocytes such as neutrophils, and is involved in the occurrence and development of kidney diseases.