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目的:研究分析盐酸伐昔洛韦片联合匹多莫德片治疗复发性生殖器疱疹的临床疗效。方法:选择2015年1月至2016年8月揭阳市普宁人民医院接诊的80例复发性生殖器疱疹患者,分成对照组和观察组各40例。对照组给予口服盐酸伐昔洛韦片治疗;观察组应用盐酸伐昔洛韦片联合匹多莫德片治疗。比较两组患者治疗前、后血清中白介素-2(IL-2)、白介素-12(IL-12)及肿瘤坏死因子-γ(TNF-γ)等炎症因子、T淋巴细胞亚群CD4~+、CD8~+、CD4~+/CD8~+水平以及疗效。结果:治疗前,两组患者血清中IL-2、IL-12、TNF-γ水平差异均无统计学意义(P>0.05);治疗后,患者血清中IL-2、IL-12、TNF-γ水平均有改善,且观察组优于对照组,差异具有统计学意义(P<0.05);治疗前,两组患者T淋巴细胞亚群CD4~+、CD8~+及CD4~+/CD8~+差异均无统计学意义(P>0.05);治疗后,患者CD4~+、CD8~+及CD4~+/CD8~+均改善,且观察组优于对照组,差异具有统计学意义(P<0.05)。结论:盐酸伐昔洛韦片联合匹多莫德片治疗复发性生殖器疱疹能够显著改善患者免疫功能。
Objective: To study the clinical efficacy of valacyclovir hydrochloride tablets combined with pidotimod tablets in the treatment of recurrent genital herpes. Methods: 80 patients with recurrent genital herpes admitted to Puning People’s Hospital of Jieyang from January 2015 to August 2016 were divided into control group and observation group of 40 cases. The control group was treated with oral valacyclovir hydrochloride tablets. The observation group was treated with valaciclovir hydrochloride tablets and pidotimod tablets. The levels of interleukin-2 (IL-2), interleukin-12 (IL-12) and tumor necrosis factor-γ (TNF-γ) and other inflammatory factors, T lymphocyte subsets CD4 + , CD8 ~ +, CD4 ~ + / CD8 ~ + levels and efficacy. Results: Before treatment, there was no significant difference in serum IL-2, IL-12 and TNF-γ between the two groups (P> 0.05). After treatment, the levels of IL-2, IL-12 and TNF- (P <0.05). Before treatment, the levels of CD4 ~ +, CD8 ~ + and CD4 ~ + / CD8 ~ + of T lymphocyte subsets in the two groups were significantly higher than those in the control group (P> 0.05). After treatment, the levels of CD4 ~ +, CD8 ~ + and CD4 ~ + / CD8 ~ + were all improved in the observation group and the difference was statistically significant (P <0.05). Conclusion: Valacyclovir hydrochloride tablets combined with pidotimod tablets in treatment of recurrent genital herpes can significantly improve immune function in patients.