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目的:探讨多种精神科药物联用伴发的外周血白细胞(WBC)数量及比值的改变,分析其临床特征及产生机制。方法:通过对78例长期应用抗精神病药物进行联合治疗的患者外周血WBC的变化,分析不同种类抗精神病药物联用与白细胞变化之间的关联性。结果:氯氮平与碳酸锂联用WBC有所上升,中性粒细胞的比值(N)有所下降,与其它药物联用,有的WBC、N下降明显,有的WBC、N改变幅度不大。结论:精神科药物的联用,所引起的外周血中粒细胞的变化,应及早引起临床医师的重视,防范意外事故的发生。
Objective: To investigate the changes of the number and ratio of peripheral blood leukocytes (WBC) associated with various psychiatric drugs and to analyze their clinical features and mechanism. Methods: The changes of WBC in peripheral blood of 78 patients who were treated with antipsychotics for a long time were analyzed. The association between different kinds of antipsychotics and leukocyte changes was analyzed. Results: The ratio of clozapine and lithium carbonate increased, the neutrophil ratio (N) decreased, and other drugs combined, and some WBC, N decreased significantly, and some changes in WBC, N amplitude Big. Conclusion: The combination of psychotropic drugs, caused by changes in peripheral blood neutrophils should be caused by clinicians as soon as possible to prevent accidents.