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目的:探讨错配修复基因hMSH2与急性白血病(AL)的关系及临床意义。方法:分别对急性淋巴细胞白血病(ALL)组和急性非淋巴细胞白血病(ANLL)组及相应对照组进行DNA斑点印迹杂交;应用岛津薄层扫描仪对上述实验结果进行扫描;扫描值采用SPSS10.0系统软件进行统计学分析。结果:ALL组与相应对照组hMSH2斑点印迹扫描结果比较,P<0.05有显著性差异;ANLL组与相应对照组比较,P>0.05无明显相关性;ALL组与ANLL组比较,P<0.05有显著性差异。结论:错配修复基因hMSH2异常可能与ALL的发病有关,而在ANLL发病过程中不起关键作用。
Objective: To investigate the relationship between mismatch repair gene hMSH2 and acute leukemia (AL) and its clinical significance. Methods: Dot blot hybridization was performed on acute lymphoblastic leukemia (ALL) group and acute non-lymphocytic leukemia (ANLL) group and corresponding control group, respectively. Shimadzu thin layer scanner was used to scan the above experimental results. The scan value was determined by SPSS10 .0 system software for statistical analysis. Results: Compared with the corresponding control group, the results of dot blotting of hMSH2 in ALL group showed significant difference (P <0.05); there was no significant correlation between ANLL group and corresponding control group, P <0.05 Significant difference. Conclusion: The mismatch repair gene hMSH2 may be related to the pathogenesis of ALL, but not to the pathogenesis of ANLL.