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目的调查南阳地区患者输注红细胞的临床病例,选取其中输血无效者,分析红细胞无效输注与低效价不规则抗体的漏检的相关性。方法选取在本市中心医院输注红细胞无效治疗患者570例,对患者血样用血清学试验重新分析检测是否存在低效价不规则抗体的漏检。结果红细胞输注无效患者570例(12.5%)中,女性比较男性χ2=36.81,P<0.01;有输血史与无输血史患者比较χ2=619.6,P<0.01;有妊娠史与无妊娠史患者比较χ2=85.5,P<0.01。因低效价不规则抗体漏检引起的输注无效71例,占红细胞输注无效的12.4%。结论南阳地区患者红细胞输注无效与低效价不规则抗体的漏检密切相关,低效价不规则抗体与患者输血史、妊娠史、输血次数、妊娠次数密切相关,我们常规的聚凝胺法容易漏检低效价的不规则抗体,用低效价的阳性对照试剂作对照以及改良聚凝胺法与抗球蛋白法联合检测可以提高检出率,避免该类患者因低效价不规则抗体漏检而导致无效输注。
Objective To investigate the clinical cases of transfusion of erythrocytes in patients with Nanyang area and to select the ones with ineffective blood transfusion and to analyze the correlation between the ineffective transfusion of erythrocytes and the undetected low antibody titer. Methods 570 cases of patients with ineffective erythrocyte infusion were selected in the central hospital of our city. The patients’ blood samples were re-analyzed by serological test to detect the presence or absence of undetectable antibodies. Results Among 570 patients (12.5%) with ineffective erythrocyte infusion, the females had χ2 = 36.81, P <0.01; the blood transfusion history was no significant difference with the patients without transfusion history (χ2 = 619.6, P <0.01) Compare χ2 = 85.5, P <0.01. 71 cases of ineffective infusion due to missed test of low antibody titer, accounting for 12.4% of invalid red blood cell transfusion. Conclusion The ineffective erythrocyte infusion in patients with Nanyang is closely related to the missed test of irregular antibody with low titer. The irregular antibody with low titer is closely related to the history of blood transfusion, the history of pregnancy, the number of blood transfusions and the number of pregnancies. Our conventional polybrene method Easily undetectable low titer of irregular antibodies, with low titer positive control reagent as a control and modified polybrene method and antiglobin method combined detection can increase the detection rate, to avoid such patients due to low titers of irregular Missing antibodies lead to invalid infusion.