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目的研究比较盐酸法舒地尔与盐酸丁咯地尔治疗椎基底动脉供血不足眩晕的疗效及安全性。方法将2008年6月-2012年6月我科收治的椎基底动脉供血不足眩晕患者88例随机分成盐酸法舒地尔组(观察组)和盐酸丁咯地尔组(对照组)各44例,比较两组患者1个疗程治疗后的临床总有效率、不良反应发生率。结果观察组治疗后总有效率97.7%,高于对照组的84.1%,组间差异有统计学意义(P<0.05);观察组不良反应发生率2.27%,低于对照组的4.55%,但组间差异具无统计学意义(P>0.05)。结论盐酸法舒地尔治疗椎基底动脉供血不足眩晕临床效果确切、效果优于盐酸丁咯地尔;两种药物均具有不良反应少、安全性高的特点,值得临床推荐。
Objective To study the efficacy and safety of fasudil hydrochloride and buflomedil hydrochloride in the treatment of Vertebrobasilar insufficiency vertigo. Methods Seventy-eight patients with Vertebrobasilar insufficiency vertigo treated in our department from June 2008 to June 2012 were randomly divided into fasudil hydrochloride group (observation group) and buflomedil hydrochloride group (control group), 44 cases The clinical total effective rate and incidence of adverse reactions after one course of treatment were compared between the two groups. Results The total effective rate in observation group was 97.7% after treatment, which was higher than that in control group (84.1%). The difference between the two groups was statistically significant (P <0.05). The adverse reaction rate in observation group was 2.27%, which was 4.55% lower than that in control group There was no significant difference between groups (P> 0.05). Conclusion Fasudil Hydrochloride is effective in vertigo treatment of Vertebrobasilar insufficiency Vertigo. The effect is better than Buflomedil Hydrochloride. Both drugs have less side effects and high safety, so it is worth recommending clinically.