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特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种慢性、进行性间质性疾病,以进行性呼吸困难和低氧血症为主要特征。以往的研究认为其发病与细胞因子如:肿瘤坏死因子-α(TNF-)α、转化生长因子-β(TGF-β)、血小板源性生长因子(PDGF)等参与的炎症和纤维化的过程有关[1
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial disease characterized by progressive dyspnea and hypoxemia. Previous studies have suggested that the pathogenesis is related to the inflammatory and fibrotic processes involved in cytokines such as tumor necrosis factor-α (TNFα), transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF) About [1