论文部分内容阅读
生物膜是一种黏附于非生物或生物表面的微生物附着群落,由多糖、蛋白或核酸等构成的多聚基质形成。生物膜结构有助于抵抗机体防御系统及增强病原体对抗生素的耐受性,与慢性、持续性感染有密切关系。细菌性阴道病妇女阴道黏膜及性伴侣尿液沉渣均能检测到加德纳菌生物膜。采用甲硝唑或莫西沙星的标准治疗,虽然临床症状消失,但停药后部分以加德纳菌为主的细菌生物膜在生化失活后得以重新复活。在外阴阴道假丝酵母菌病患者的宫内节育环表面,以及小鼠白假丝酵母菌阴道炎模型上均检测到白假丝酵母菌生物膜。生物膜的研究将对阴道炎症的认识提供一种全新思路。
Biofilm is a microbial attachment that adheres to non-biological or biological surfaces and is formed from a matrix of polysaccharides, proteins, or nucleic acids. Biofilm structure helps to resist the body’s defense system and enhance the tolerance of pathogens to antibiotics, which is closely related to chronic and persistent infection. Bacterial vaginosis women vaginal mucosa and sexual partner urine sediment can detect Gardnerella biofilm. Metronidazole or moxifloxacin standard treatment, although the clinical symptoms disappear, but after stopping part of Gardnerella-based bacterial biofilms in the biochemical inactivation to be revived. Candida albicans biofilms were detected on the surface of IUD in patients with vulvovaginal candidiasis and in the mouse model of C. albicans vaginitis. Biofilm research will provide a new idea of vaginal inflammation.