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目的探讨应用国产肺表面活性物质(PS)珂立苏联合鼻塞持续正压通气(CPAP)治疗新生儿呼吸窘迫综合征(NRDS)的临床疗效。方法对43例确诊为NRDS的患者早期给予气管插管-PS-拔管应用CPAP(INSURE技术)治疗,观察治疗前后临床症状,血气分析的变化及并发症情况。结果 43例患儿经INSURE技术治疗后临床症状明显改善,6、24、48 h血pH值,氧分压(PO2),二氧化碳分压(PCO2),吸入氧浓度(FiO2),呼气末正压(PEEP)均较用药前明显改善,差异有统计学意义(P<0.05)。结论肺表面活性物质联合鼻塞持续正压通气可发挥协同作用,能减轻NRDS的程度,改善血氧饱和度,减少机械通气的应用。
Objective To investigate the clinical effect of domestic use of pulmonary surfactant (PS) Ke Li Su with continuous positive airway pressure (CPAP) in the treatment of neonatal respiratory distress syndrome (NRDS). Methods 43 patients diagnosed as NRDS were given tracheal intubation and PS-extubation by CPAP (INSURE technique). The clinical symptoms, changes of blood gas analysis and complication were observed before and after treatment. Results The clinical symptoms of 43 children were significantly improved after treatment with INSURE. The blood pH, PO2, PCO2, FiO2, Pressure (PEEP) were significantly improved compared with before treatment, the difference was statistically significant (P <0.05). Conclusions Pulmonary surfactant combined with continuous positive airway pressure of nasal obstruction can play a synergistic role, which can reduce the degree of NRDS, improve oxygen saturation and reduce the application of mechanical ventilation.