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肝素不仅具有抗凝作用,而且还有广泛的生化和药理作用。业已证实,肝素具有强大的抗补体作用,其作用点在补体系统的多个环节上,影响补体传统途径、旁路途径的激活及其调控机制。补体一方面参与体内的免疫防疫机制,其中包括补体对免疫复合物的溶解能力(Complement-mediatedimmune complex solubilizing capacity,CMSC)和抑制免疫复合物沉淀的能力(Im-mune complex precipitation inhibitioncapacity,ICPIC),在机体清除免疫复合物的机制中发挥重要作用;另一方面,补体被激活后的产物又能引起一系列组织损伤。肝
Heparin is not only anticoagulant, but also has a wide range of biochemical and pharmacological effects. It has been confirmed that heparin has a strong anti-complement effect, its role in a number of aspects of the complement system, affecting the traditional complement of the pathway, the activation of the bypass pathway and its regulatory mechanism. On the one hand, complement is involved in the immune mechanism in vivo, including Complement-mediated immune complex solubilization capacity (CMSC) and immune complex precipitation inhibition capacity (ICPIC) The body plays an important role in the mechanism of clearance of immune complexes. On the other hand, the products activated by complement can cause a series of tissue damage. liver