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为了观察职业铅接触人群血清热应激蛋白70的变化,探讨热应激蛋白作为职业铅接触敏感生物标志物的可能性,对铅作业工人进行血清中热应激蛋白70水平的调查。以其蓄电池厂铅接触工人72人为铅暴露组,不接触铅及其他职业有害因素工人41人作为对照组。用ELISA方法检测工人血清中热应激蛋白70的水平,血铅水平用原子吸收光谱法进行检测,尿铅水平用微分电位溶出法检测。结果显示,暴露组工人中血清热应激蛋白70及血铅的水平均明显高于对照组,差异均具有非常显著性(P<0.01),两组人群尿铅水平差异无显著性(P>0.05);血清中热应激蛋白的水平与血铅水平有相关性(r=0.501,P<0.01),而与尿铅无明显的相关性(r=0.181,P>0.05)。提示,血清中热应激蛋白70的水平可反映职业铅接触的情况,作为生物标志物在铅作业工人健康监护中有一定的价值。
In order to observe the changes of serum heat stress protein 70 in occupational lead exposure population and to explore the possibility of heat stress protein as a sensitive biomarker of occupational lead exposure, the level of serum heat stress protein 70 in lead workers was investigated. With its battery factory lead exposure workers 72 lead exposure group, do not contact with lead and other occupational hazards 41 workers as a control group. The levels of heat stress protein 70 in serum of workers were detected by ELISA, the level of blood lead was detected by atomic absorption spectrometry, and the level of urinary lead was detected by differential potentiometric stripping method. The results showed that the levels of serum heat stress protein 70 and blood lead in exposed group were significantly higher than those in control group (P <0.01), and there was no significant difference in urinary lead levels between the two groups (P> 0.05). The level of heat stress protein in serum was correlated with blood lead level (r = 0.501, P <0.01), but not with urine lead (r = 0.181, P> 0.05). Tip, the level of serum heat stress protein 70 can reflect the situation of occupational lead exposure, as a biomarker in lead health workers have some value.