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Objectives. The aim of this study was to investigate the expression of the pro apoptotic protein Apaf-1 in cervical cancers. Moreover, we studied its correlat ion to intratumoral pO2 and to clinico-pathological parameters. Methods. 86 pat ients with cervical cancer were subjected to intratumoral pO2 measurement with t he Eppendorf electrode. From these patients, cervical cancer tissue was used for immunohistochemistry with an anti-Apaf-1 antibody. Results. Apaf-1 is expres sed in cervical cancer. Cervical cancers with strong or moderate Apaf-1 express ion had significantly less lymph node metastases at time of surgery than tumors with weak or negative Apaf-1 expression (P = 0.022). There was no significant c orrelation between Apaf-1 expression and intratumoral pO2,pT stage, FIGO stage, lymphovascular space involvement, and grade. Conclusions. Loss of Apaf-1 expre ssion may represent a marker of aggressive tumor behavior since it correlates si gnificantly with the occurrence of lymph node metastasis in cervical cancer.
Objectives. This aim of this study was to investigate the expression of the pro apoptotic protein Apaf-1 in cervical cancers. Moreover, we studied its correlat ion to intratumoral pO2 and to clinico-pathological parameters. Methods. 86 pat ients with cervical cancer were From these patients, cervical cancer tissue was used for immunohistochemistry with an anti-Apaf-1 antibody. Results. Apaf-1 is expres sed in cervical cancer. Cervical cancers with strong or moderate Apaf -1 express ion had significantly less lymph node metastases at time of surgery than tumors with weak or negative Apaf-1 expression (P = 0.022). There was no significant c orrelation between Apaf-1 expression and intratumoral pO2, pT stage, FIGO stage , lymphovascular space involvement, and grade. Conclusions. Loss of Apaf-1 expre ssion may represent a marker of aggressive tumor behavior since it correlates si gnificantly with the occurrence of lymph n ode metastasis in cervical cancer.